How does BOTOX® work? BOTOX® injections temporarily block the chemical signals from the nerves that stimulate the sweat glands. When the sweat glands don't receive chemical signals, the production of excessive sweat stops in the treated areas only. Sweat continues to be produced elsewhere. Where does the sweat go? Your sweat doesn't go anywhere or get backed up, because the sweat simply isn't produced in the areas treated with BOTOX®. Remember, the rest of your body is free to release moisture normally. And if you were to stop BOTOX® treatment, the sweating function would return to normal. How effective is BOTOX® treatment? BOTOX® neurotoxin treatment is proven. Clinical studies found that:
  • 57 out of 104 patients treated with BOTOX® (55%) achieved an effective response, compared to only 6 out of 108 treated without BOTOX® (6%). "Effective response" is defined as an improvement of at least 2 grades on the Hyperhidrosis Disease Severity Scale (HDSS)
  • 84 out of 104 patients treated with BOTOX® (81%) achieved a greater than 50% reduction in sweating, compared to only 44 out of 108 treated without BOTOX® (41%)
Please see Important Safety Information. What are the possible side effects of BOTOX®? BOTOX® can cause serious side effects. Other side effects of BOTOX® include: dry mouth, discomfort or pain at the injection site, tiredness, headache, neck pain, and eye problems: double vision, blurred vision, decreased eyesight, drooping eyelids, swelling of your eyelids, and dry eyes. Symptoms of an allergic reaction to BOTOX® may include: itching, rash, red itchy welts, wheezing, asthma symptoms, or dizziness or feeling faint. Tell your doctor or get medical help right away if you are wheezing or have asthma symptoms, or if you become dizzy or faint. Tell your doctor if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of BOTOX®. For more information, ask your doctor or pharmacist. How long does a BOTOX® treatment last?

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In a clinical study, the median duration of response in BOTOX ® patients was 201 days or 6.7 months. (This means that half the patients had a treatment duration of at least 201 days or 6.7 months.) BOTOX ® injections are not a cure—your symptoms will gradually return and you will know when the time is right for another treatment. Your dermatologist will recommend a treatment strategy to ensure that you receive the best possible results with BOTOX ® treatment.
What is the next step? Talk to a dermatologist about your condition and about BOTOX® treatment. Possibly your underarm sweating can be managed by a topical agent, like an antiperspirant or deodorant containing an aluminum-based compound. If that doesn’t work, BOTOX® treatment may be right for you. Is BOTOX® treatment right for you? In order to make the right treatment decision, discuss the following with your dermatologist:
  • Your dermatologist's experience with BOTOX® treatment
  • Effectiveness and important safety information about BOTOX® injections
 You should tell your dermatologist about all your medical conditions, including if you have:
  • a disease that affects your muscles and nerves (such as amyotrophic lateral sclerosis [ALS or Lou Gehrig's disease], myasthenia gravis or Lambert-Eaton syndrome). See "What is the most important information I should know about BOTOX®?"
  • allergies to any botulinum toxin product
  • had any side effect from any botulinum toxin product in the past
  • a breathing problem, such as asthma or emphysema
  • swallowing problems
  • bleeding problems
  • plans to have surgery
  • had surgery on your face
  • weakness of your forehead muscles, such as trouble raising your eyebrows
  • drooping eyelids
  • any other change in the way your face normally looks
  • are pregnant or plan to become pregnant. It is not known if BOTOX® can harm your unborn baby.
  • are breast-feeding or plan to breastfeed. It is not known if BOTOX® passes into breast milk.
 Tell your doctor about all the medicines you take, including prescription and nonprescription medicines, vitamins and herbal products. For further information, please refer to the Medication Guide and make sure you talk to your dermatologist. What is treatment with BOTOX® like? The actual treatment takes about 10 to 15 minutes. A small amount of BOTOX® solution is injected into the affected underarm area through a very fine needle. The needle is placed just under the skin, so you may experience some injection-related discomfort. The most common side effects following injection include injection-site pain and bleeding, non-underarm sweating, infection, sore throat, flu, headache, fever, neck or back pain, itching and anxiety. You'll receive about 15 injections during the session, based on your dermatologist's assessment of the area that needs to be treated. Bear in mind that BOTOX® treatment is not appropriate for all sufferers. Your dermatologist and you will decide if it's right for you. What happens after treatment? You should notice a significant reduction in underarm sweating within 4 weeks of your first treatment. Once the treatment becomes effective, you may be able to stop using dress shields and carrying extra changes of clothing, and you can probably use a regular deodorant instead of a prescription antiperspirant. There is a possibility that some sweat glands may be missed, and you may continue to experience some sweating from the untreated areas. If you do not see a significant reduction in sweating, you should contact your dermatologist and request a follow-up consultation.
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