BOTOX® (onabotulinumtoxinA) Important Information

Indication
BOTOX® is injected into the skin to treat the symptoms of severe underarm sweating (severe primary axillary hyperhidrosis) when medicines used on the skin (topical) do not work well enough in people 18 years and older.

It is not known whether BOTOX® is safe or effective for severe sweating anywhere other than your armpits.

IMPORTANT SAFETY INFORMATION
BOTOX® may cause serious side effects that can be life threatening. Call your doctor or get medical help right away if you have any of these problems any time (hours to weeks) after injection of BOTOX®:

There has not been a confirmed serious case of spread of toxin effect away from the injection site when BOTOX® has been used at the recommended dose to treat severe underarm sweating.

Do not take BOTOX® if you: are allergic to any of the ingredients in BOTOX® (see Medication Guide for ingredients); had an allergic reaction to any other botulinum toxin product such as Myobloc® (rimabotulinumtoxinB), Dysport® (abobotulinumtoxinA), or Xeomin® (incobotulinumtoxinA); have a skin infection at the planned injection site.

The dose of BOTOX® is not the same as, or comparable to, another botulinum toxin product.

Serious and/or immediate allergic reactions have been reported. These reactions include itching, rash, red itchy welts, wheezing, asthma symptoms, or dizziness or feeling faint. Tell your doctor or get medical help right away if you experience any such symptoms; further injection of BOTOX® should be discontinued.

Tell your doctor about all your muscle or nerve conditions such as amyotrophic lateral sclerosis (ALS or Lou Gehrig's disease), myasthenia gravis, or Lambert-Eaton syndrome, as you may be at increased risk of serious side effects including severe dysphagia (difficulty swallowing) and respiratory compromise (difficulty breathing) from typical doses of BOTOX®.

Tell your doctor about all your medical conditions, including if you: have or have had bleeding problems; have plans to have surgery; had surgery on your face; weakness of forehead muscles, such as trouble raising your eyebrows; drooping eyelids; any other abnormal facial change; are pregnant or plan to become pregnant (it is not known if BOTOX® can harm your unborn baby); are breastfeeding or plan to breastfeed (it is not known if BOTOX® passes into breast milk).

Tell your doctor about all the medicines you take, including prescription and nonprescription medicines, vitamins, and herbal products. Using BOTOX® with certain other medicines may cause serious side effects. Do not start any new medicines until you have told your doctor that you have received BOTOX® in the past.

Especially tell your doctor if you: have received any other botulinum toxin product in the last 4 months; have received injections of botulinum toxin such as Myobloc®, Dysport®, or Xeomin® in the past (be sure your doctor knows exactly which product you received); have recently received an antibiotic by injection; take muscle relaxants; take an allergy or cold medicine; take a sleep medicine; take anti-platelets (aspirin-like products) or anti-coagulants (blood thinners).

Other side effects of BOTOX® include: dry mouth, discomfort or pain at the injection site, tiredness, headache, neck pain, and eye problems: double vision, blurred vision, decreased eyesight, drooping eyelids, swelling of your eyelids, and dry eyes.

For more information refer to the Medication Guide or talk with your doctor.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Please see BOTOX® full Product Information including Boxed Warning and Medication Guide.

CARD USAGE STATEMENT
Your BOTOX® Savings Card may only be used at hospitals, physician offices, and pharmacies, and will not be accepted at any other location that normally accepts Visa® Debit cards. The BOTOX® Savings Card cannot be used at merchants outside the United States (including Internet and mail/telephone merchants).

The BOTOX® Savings Card is issued by Metropolitan Commercial Bank, member FDIC, pursuant to license by Visa USA, Inc. ““Metropolitan Commercial Bank”” and “““Metropolitan”” are registered trademarks of Metropolitan Commercial Bank ©2014. See the Cardholder Agreement for Terms and Conditions. By accepting, signing, or using this savings card, you agree to the Terms and Conditions of the Cardholder Agreement. This savings card will remain the property of the issuing institution and the privilege of its use may be withdrawn at any time.

TERMS AND CONDITIONS
By participating, you understand and agree to comply with the Program rules as set forth below.

Offer is valid only for BOTOX® and BOTOX® treatment-related costs not covered by your insurance plan. The BOTOX® Savings Card will be funded upon approval of your claim. Your claim must be submitted with your Explanation of Benefits (EOB) or your Specialty Pharmacy Provider (SPP) receipt. (If your BOTOX® prescription was filled by a Specialty Pharmacy Provider, you must send both your EOB and SPP receipt.)

All claims must be submitted within 90 days of the date of service listed on the EOB. BOTOX® Savings Card may not be combined with any other offer or discount. This BOTOX® Savings Card is not health insurance.

Offer not valid for cash-paying patients or for patients participating in Medicare, Medicaid, or any similar federal or state healthcare program, including any state medical or pharmaceutical assistance programs. If patients are eligible for drug benefits under any such program, they cannot use this BOTOX® Savings Card. Offer void where prohibited by law, taxed, or restricted. Offer good only in the United States. Allergan, Inc., reserves the right to rescind, revoke, and amend this offer without notice.

References: 1. BOTOX® Prescribing Information, February 2014. 2. U.S. National Library of Medicine. National Institutes of Health (NIH). MedlinePlus website. http://www.nlm.nih.gov/medlineplus/ency/article/007259.htm. Updated May 21, 2013. Accessed October 22, 2014. 3. U.S. National Library of Medicine. National Institutes of Health (NIH). MedlinePlus website. http://www.nlm.nih.gov/medlineplus/ency/article/003218.htm. Updated April 24, 2013. Accessed October 1, 2014. 4. Solish N, Bertucci V, Dansereau A, et al. A comprehensive approach to the recognition, diagnosis, and severity-based treatment of focal hyperhidrosis: recommendations of the Canadian Hyperhidrosis Advisory Committee. Dermatol Surg. 2007;33(8):908-923. 5. American Academy of Dermatology (AAD). Hyperhidrosis: Diagnosis and treatment. AAD website. http://www.aad.org/dermatology-a-to-z/diseases-and-treatments/e---h/hyperhidrosis/hyperhidrosis-diagnosis-and-treatment. Accessed October 23, 2014. 6. International Hyperhidrosis Society. OnabotulinumtoxinA Injections (BOTOX®). International Hyperhidrosis Society website. http://www.sweathelp.org/en/hyperhidrosis-treatments/botox.html. Updated 2014. Accessed October 23, 2014.

BOTOX® (onabotulinumtoxinA) Important Information

Indication
BOTOX® is injected into the skin to treat the symptoms of severe underarm sweating (severe primary axillary hyperhidrosis) when medicines used on the skin (topical) do not work well enough in people 18 years and older.

It is not known whether BOTOX® is safe or effective for severe sweating anywhere other than your armpits.

IMPORTANT SAFETY INFORMATION
BOTOX® may cause serious side effects that can be life threatening. Call your doctor or get medical help right away if you have any of these problems any time (hours to weeks) after injection of BOTOX®:

There has not been a confirmed serious case of spread of toxin effect away from the injection site when BOTOX® has been used at the recommended dose to treat severe underarm sweating.

Do not take BOTOX® if you: are allergic to any of the ingredients in BOTOX® (see Medication Guide for ingredients); had an allergic reaction to any other botulinum toxin product such as Myobloc® (rimabotulinumtoxinB), Dysport® (abobotulinumtoxinA), or Xeomin® (incobotulinumtoxinA); have a skin infection at the planned injection site.

The dose of BOTOX® is not the same as, or comparable to, another botulinum toxin product.

Serious and/or immediate allergic reactions have been reported. These reactions include itching, rash, red itchy welts, wheezing, asthma symptoms, or dizziness or feeling faint. Tell your doctor or get medical help right away if you experience any such symptoms; further injection of BOTOX® should be discontinued.

Tell your doctor about all your muscle or nerve conditions such as amyotrophic lateral sclerosis (ALS or Lou Gehrig's disease), myasthenia gravis, or Lambert-Eaton syndrome, as you may be at increased risk of serious side effects including severe dysphagia (difficulty swallowing) and respiratory compromise (difficulty breathing) from typical doses of BOTOX®.

Tell your doctor about all your medical conditions, including if you: have or have had bleeding problems; have plans to have surgery; had surgery on your face; weakness of forehead muscles, such as trouble raising your eyebrows; drooping eyelids; any other abnormal facial change; are pregnant or plan to become pregnant (it is not known if BOTOX® can harm your unborn baby); are breastfeeding or plan to breastfeed (it is not known if BOTOX® passes into breast milk).

Tell your doctor about all the medicines you take, including prescription and nonprescription medicines, vitamins, and herbal products. Using BOTOX® with certain other medicines may cause serious side effects. Do not start any new medicines until you have told your doctor that you have received BOTOX® in the past.

Especially tell your doctor if you: have received any other botulinum toxin product in the last 4 months; have received injections of botulinum toxin such as Myobloc®, Dysport®, or Xeomin® in the past (be sure your doctor knows exactly which product you received); have recently received an antibiotic by injection; take muscle relaxants; take an allergy or cold medicine; take a sleep medicine; take anti-platelets (aspirin-like products) or anti-coagulants (blood thinners).

Other side effects of BOTOX® include: dry mouth, discomfort or pain at the injection site, tiredness, headache, neck pain, and eye problems: double vision, blurred vision, decreased eyesight, drooping eyelids, swelling of your eyelids, and dry eyes.

For more information refer to the Medication Guide or talk with your doctor.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Please see BOTOX® full Product Information including Boxed Warning and Medication Guide.

CARD USAGE STATEMENT
Your BOTOX® Savings Card may only be used at hospitals, physician offices, and pharmacies, and will not be accepted at any other location that normally accepts Visa® Debit cards. The BOTOX® Savings Card cannot be used at merchants outside the United States (including Internet and mail/telephone merchants).

The BOTOX® Savings Card is issued by Metropolitan Commercial Bank, member FDIC, pursuant to license by Visa USA, Inc. ““Metropolitan Commercial Bank”” and “““Metropolitan”” are registered trademarks of Metropolitan Commercial Bank ©2014. See the Cardholder Agreement for Terms and Conditions. By accepting, signing, or using this savings card, you agree to the Terms and Conditions of the Cardholder Agreement. This savings card will remain the property of the issuing institution and the privilege of its use may be withdrawn at any time.

TERMS AND CONDITIONS
By participating, you understand and agree to comply with the Program rules as set forth below.

Offer is valid only for BOTOX® and BOTOX® treatment-related costs not covered by your insurance plan. The BOTOX® Savings Card will be funded upon approval of your claim. Your claim must be submitted with your Explanation of Benefits (EOB) or your Specialty Pharmacy Provider (SPP) receipt. (If your BOTOX® prescription was filled by a Specialty Pharmacy Provider, you must send both your EOB and SPP receipt.)

All claims must be submitted within 90 days of the date of service listed on the EOB. BOTOX® Savings Card may not be combined with any other offer or discount. This BOTOX® Savings Card is not health insurance.

Offer not valid for cash-paying patients or for patients participating in Medicare, Medicaid, or any similar federal or state healthcare program, including any state medical or pharmaceutical assistance programs. If patients are eligible for drug benefits under any such program, they cannot use this BOTOX® Savings Card. Offer void where prohibited by law, taxed, or restricted. Offer good only in the United States. Allergan, Inc., reserves the right to rescind, revoke, and amend this offer without notice.

References: 1. BOTOX® Prescribing Information, February 2014. 2. U.S. National Library of Medicine. National Institutes of Health (NIH). MedlinePlus website. http://www.nlm.nih.gov/medlineplus/ency/article/007259.htm. Updated May 21, 2013. Accessed October 22, 2014. 3. U.S. National Library of Medicine. National Institutes of Health (NIH). MedlinePlus website. http://www.nlm.nih.gov/medlineplus/ency/article/003218.htm. Updated April 24, 2013. Accessed October 1, 2014. 4. Solish N, Bertucci V, Dansereau A, et al. A comprehensive approach to the recognition, diagnosis, and severity-based treatment of focal hyperhidrosis: recommendations of the Canadian Hyperhidrosis Advisory Committee. Dermatol Surg. 2007;33(8):908-923. 5. American Academy of Dermatology (AAD). Hyperhidrosis: Diagnosis and treatment. AAD website. http://www.aad.org/dermatology-a-to-z/diseases-and-treatments/e---h/hyperhidrosis/hyperhidrosis-diagnosis-and-treatment. Accessed October 23, 2014. 6. International Hyperhidrosis Society. OnabotulinumtoxinA Injections (BOTOX®). International Hyperhidrosis Society website. http://www.sweathelp.org/en/hyperhidrosis-treatments/botox.html. Updated 2014. Accessed October 23, 2014.

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